TASE

Higher Edu - Research dev card
Development from the higher education and research community
  • Creation or important update: 02/05/11
  • Minor correction: 02/05/11

TASE : online tool for searching candidate regions from SNPs data

This software was developed (or is under development) within the higher education and research community. Its stability can vary (see fields below) and its working state is not guaranteed.
  • Web site
  • System:
  • Current version: 5.0 - 11/01/2011
  • Status: internal use
  • Support: maintained, ongoing development
  • Designer(s): M.HEBRARD, C.HAMEL, G.MANES, I.MOUGENOT
  • Contact designer(s): maxime.hebrard@inserm.fr
  • Laboratory, service:

 

General software features

TASE is a webtool dedicated to the study of hereditary diseases.

  • From a whole-genome SNP scan (Single Nucleotide Polymorphism), the soft identifying candidate regions which could contain the gene causing the disease.
  • TASE analyze data of DNA chips from 10K to 900K.
  • TASE have a web interface and is easy to use.

language: Javascript and Perl-cgi.

Other functions :

  • Display family tree using cranefoot (French cranefoot card).
  • Specific tests according family profile : autosomal dominante or recessive transmission, consanguineous family or not.
  • Select whitch individual you want to test and his status (sick or healthy).
  • Display graphic results in whole genome view or chromosome specific.
Context in which the software is used

Our team study hereditary retinal distrophies that are monogenic and very heterogeneous diseases.
TASE analyzes whole genome data (SNP chips) and display candidate regions.
Then these regions are sequencing to identify causative mutation.

Exemple of use :

  • Autosomal dominante transmission:
    • Identifying causative gene among known genes.
    • Finding unknown gene or locus in large family.
  • Autosomal recessive transmission:

    • Identifying causative gene among known genes, even small family (only 3 individuals).